1. No. 8 Ole Miss at No. 13 Oklahoma: Rare Intersectional Matchup in Norman These programs have only met twice in history—in 1999 and 2024—with Oklahoma winning both meetings. Ole Miss (6-1) is looking to rebound after their loss to Georgia last week, but faces one of the nation’s best defenses in Norman. Oklahoma (6-1) seeks to extend their perfect record against the Rebels and solidify their SEC credentials. This rare matchup between two storied programs highlights how infrequently the old Big Eight/Big 12 powers faced traditional SEC teams before conference realignment.
2. No. 3 Texas A&M at No. 20 LSU: Battle in Death Valley Texas A&M currently holds a 1-game win streak in a series where LSU once dominated with a 6-game streak from 1960-1965. The Aggies countered with their own 5-game run from 1991-1995. A&M enters 7-0 as the last undefeated SEC team looking to continue their dominance, while LSU (5-2) desperately needs a signature win in Death Valley to salvage their playoff hopes. This primetime matchup could determine who stays alive in the SEC Championship race.
3. No. 10 Vanderbilt at No. 15 Missouri: Commodores Seek to End 5-Game Losing Streak Missouri has won five straight against Vanderbilt (2020-2024), including a brutal 41-0 shutout in 2020. Vanderbilt (6-1) has surged into the top-10 after their historic upset of Alabama, but Missouri (6-1) has been their nemesis. The Commodores need to break through against the Tigers to prove their remarkable season is sustainable and establish themselves as legitimate SEC contenders rather than a one-upset wonder.
4. No. 11 BYU at Iowa State: Cougars’ Perfect Season on the Line in Ames BYU enters undefeated at 7-0 but faces a major test in Ames, one of college football’s toughest road environments. Iowa State (5-2) desperately needs a bounce-back win, and Jack Trice Stadium has been a house of horrors for ranked visitors. The Cyclones need this game to stay relevant in the Big 12 race, while BYU looks to prove their undefeated record isn’t a mirage built on a soft schedule.
5. No. 2 Indiana vs UCLA: Hoosiers’ Dream Season Faces Team That Beat Penn State Indiana (7-0) hosts the same UCLA team that shocked Penn State earlier this season with the most improbable upset of the year. The Bruins enter as massive underdogs, but they’ve already proven they can take down a Big Ten power. Indiana is in uncharted territory with their historic start and cannot afford a trap game against a team that specializes in spoiling perfect seasons.
6. No. 17 Tennessee at Kentucky: Wildcats Playing Giant-Killer - Kentucky is 0-4 in SEC play but has been incredibly competitive, losing by just 7 to Ole Miss (30-23) and by 3 to Texas (16-13) at home, making them a dangerous spoiler for Tennessee’s playoff hopes.
7. No. 25 Michigan at Michigan State: Battle for the Paul Bunyan Trophy - The in-state rivalry for the Paul Bunyan Trophy returns with both teams needing a win to stay relevant in the Big Ten race.